In contrast to conventional drugs, nucleic acid-based therapies enable targeted intervention at the molecular level.

Analysis of two randomized clinical trials.

A study carried out by Dr. Marco Witkowski during a research stay at the Cleveland Clinic in Ohio/USA provides new insights into the potential health risks of the widely used sweetener xylitol.

Prof. Ulf Landmesser, MD, Director of the FRIEDE SPRINGER - Cardiovascular Prevention Center, summarizes findings from the PARTNER 3 study in an editorial for the New England Journal of Medicine (NEJM). The editorial underscores the urgent need for novel strategies to prevent the progression of valvular heart diseases, particularly aortic valve stenosis, a prevalent condition.

In previous studies, PAGln was associated with the presence of heart failure in patients and showed potentially negative effects on heart muscle cells in experiments. In this study, we investigated whether PAGln levels in the blood have any significance for the prognosis of patients with stable heart failure.

This study investigates an innovative molecular therapy approach for the prevention of heart attacks.

To what extent are prevention strategies for cardiovascular diseases actually implemented in European countries?

From mechanisms to clinical implementation

Artificial sweeteners such as erythritol are used as sugar substitutes in many foods and drinks, especially processed ones.