Precision Cardiovascular Disease

In many areas of medicine, treatment strategies are already highly personalized. In the case of cardiovascular disease, however, cardiology still predominantly treats patients according to standardized guidelines that apply equally to all affected individuals. Although these approaches are generally very effective, they have so far only taken individual differences into account to a limited extent.

This is precisely where the study Precision Cardiovascular Disease (Precision CVD) comes in.

Precision CVD aims to take cardiovascular medicine to the next level: from the current, still highly standardized treatment to more precise therapy tailored to individual patients.

Precision CVD study

  • Inclusion of up to 2000 patients
  • Duration of study: 10 years
  • Follow-up: 1 year & 3 years after study initiation
Precision CVD study: Risk factors for cardiovascular disease
Precision CVD: Observational study by the FS-CPC at Charité Campus Benjamin Franklin (CBF)

What is Precision CVD?

Precision CVD is a prospective, single-center observational study of FS-CPC at Charité Campus Benjamin Franklin (CBF) in the field of secondary prevention.

This means that this study will only be conducted at Charité on the Benjamin Franklin campus and is aimed at people who already have cardiovascular disease or corresponding findings and for whom serious events or secondary diseases should be prevented as early as possible.

Precision CVD aims to help identify previously unknown individual risk factors for the development and progression of heart disease. In this way, secondary prevention, i.e., protection against the progression of the disease, is to be specifically strengthened.

The aim of the study is to be able to provide heart patients with personalized therapy recommendations for secondary prevention in the future, based on their personal risk profile and thus their individual needs.

Adult patients who are interested in participating in the Precision CVD study must undergo invasive cardiological diagnostics (such as a cardiac catheterization) at the CBF. cardiac catheterization) and who agree to participate in the study.

What is being investigated?

In addition to regular therapy, additional information is collected to identify individual stress factors and risk factors:

  • Analysis of blood, urine, and stool samples
  • Evaluation of a personal, detailed study questionnaire, which covers not only known risk factors but also a wide range of other possible influencing factors.

These measures require only minimal effort on the part of participants. However, they enable a much deeper understanding of why cardiovascular diseases develop and progress differently in each individual.

 

Why is this important?

Precision CVD is intended to help further refine the already very high quality of standard medical treatment and, in the future...

  • ...identify individual risk profiles even more accurately
  • ...derive additional, highly specific therapy recommendations
  • ...making cardiological treatment more targeted, personalized, and effective in the long term

Follow-up examinations after 1 and 3 years also enable a long-term assessment of the course of the disease.

 

 

Project staff

  • Professor Ulf Landmesser
  • Dr. Marco Wittkowski
  • Dr. Corinna König