New study warns of increased risk of heart disease from xylitol sweetener

A recent study led by Dr. Marco Witkowski of the Friede Springer - Cardiovascular Prevention Center revealed a significant association between xylitol levels in blood and increased cardiovascular risk. This included a 57% higher likelihood of heart attacks, strokes, or death among individuals with elevated xylitol concentrations. Laboratory tests confirmed that xylitol enhances platelet reactivity, promoting clot formation and increasing cardiovascular risks. While often marketed as a safe alternative, these findings call for more rigorous safety studies, particularly for individuals with existing cardiovascular risks.

Xylitol and its Widespread Use

Xylitol, often referred to as "birch sugar," is a sugar alcohol used in various foods and beverages due to its low-calorie content and neutral taste. It is also commonly included in dental care products like toothpaste, lozenges, and chewing gum because of its purported anti-cavity properties. Classified as "Generally Recognized as Safe" (GRAS) by health authorities in the USA and the European Union, xylitol is endorsed by several organizations for people with risk factors like obesity or diabetes.

Study Implementation and Findings

Blood samples from over 3,300 cardiovascular patients were analyzed over three years. Results showed that patients with elevated xylitol levels in their blood had a significantly increased risk of heart attacks, strokes, or death—specifically, a 57% higher likelihood of severe cardiac events. Laboratory tests and trials with healthy participants confirmed that xylitol heightens platelet activity, leading to greater clot formation and an elevated risk of cardiovascular complications. These findings challenge the assumption that sugar alcohols like xylitol are entirely safe alternatives.

Scientific recognition and recommendations

Dr. Witkowski’s work was recognized with the Josef Freitag Foundation Science Prize, underscoring its importance in healthcare research. Given xylitol's widespread use in food and dental products, researchers stress the importance of further studies to understand its potential health risks. The findings highlight that xylitol may not be as harmless as widely believed, especially for those with pre-existing cardiovascular issues. Dr. Witkowski advises consumers to be aware of these potential risks and consult healthcare professionals if unsure about xylitol consumption.

Publication in the "European Heart Journal":